AURKB (Aurora Kinase B) is a chromosome passenger complex protein essential for mitosis and cytokinesis. It plays critical roles in chromosome alignment, kinetochore function, and cell division. While essential for cell proliferation, dysregulated AURKB has been implicated in neurodegeneration through its roles in cell cycle control and genomic stability[1].
| Property | Value |
|---|---|
| Gene Symbol | AURKB |
| Gene Name | Aurora Kinase B |
| Aliases | AURORA-B, STK12 |
| Chromosomal Location | 17p13.1 |
| NCBI Gene ID | 9212 |
| UniProt ID | Q96GD4 |
| Ensembl ID | ENSG00000178999 |
| Gene Type | Protein Coding |
AURKB is part of the chromosome passenger complex (CPC):
AURKB forms a complex with INCENP, Survivin, and Borealin[2].
AURKB performs essential mitotic functions:
AURKB is expressed in:
In neurons, AURKB expression is typically very low but may be upregulated under certain stress conditions.
Aberrant cell cycle activity contributes to neurodegeneration:
AURKB is primarily a cancer therapeutic target:
| Disease | Evidence Level | Mechanism |
|---|---|---|
| Cancer | Confirmed | Cell proliferation |
| Neurodegeneration | Moderate | Cell cycle re-entry |
| Aneuploidy | Confirmed | Chromosome segregation |
AURKB interacts with CPC components:
| Protein | Interaction | Function |
|---|---|---|
| INCENP | Core complex | Inner centromere protein |
| Survivin | Core complex | Chromosome passenger |
| Borealin | Core complex | Complex stability |
Carmena M et al. The chromosome passenger complex (CPC): a key regulator of chromosome segregation and cytokinesis. 2009. ↩︎
Hindriksen S et al. The emerging role of Aurora B in the DNA damage response. 2017. ↩︎