| RPS6KB2 | |
|---|---|
| Symbol | RPS6KB2 |
| Full Name | Ribosomal Protein S6 Kinase B2 |
| Chromosome | 11q13.2 |
| NCBI Gene ID | [6199](https://www.ncbi.nlm.nih.gov/gene/6199) |
| OMIM | [608939](https://www.omim.org/entry/608939) |
| Ensembl | [ENSG00000137142](https://ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000137142) |
| UniProt | [Q9UQ88](https://www.uniprot.org/uniprot/Q9UQ88) |
| Associated Diseases | Cancer, metabolic syndrome, neurodegeneration |
SAP97 is a human gene whose product rPS6KB2 (also known as p70β or S6K2) is a member of the ribosomal protein S6 kinase family. It is activated by mTORC1 and plays important roles in protein synthesis, cell growth, and proliferation. In the brain, RPS6KB2 is involved in synaptic plasticity and memory formation. Dysregulated mTOR/S6K signaling is implicated in Alzheimer's disease, where hyperactivation of this pathway contributes to aberrant protein synthesis and synaptic dysfunction. RPS6KB2 also phosphorylates proteins involved in tau pathology. This page covers the gene's normal function, disease associations, expression patterns, and key research findings relevant to neurodegeneration.
RPS6KB2 (also known as p70β or S6K2) is a member of the ribosomal protein S6 kinase family. It is activated by mTORC1 and plays important roles in protein synthesis, cell growth, and proliferation. In the brain, RPS6KB2 is involved in synaptic plasticity and memory formation. Dysregulated mTOR/S6K signaling is implicated in Alzheimer's disease, where hyperactivation of this pathway contributes to aberrant protein synthesis and synaptic dysfunction. RPS6KB2 also phosphorylates proteins involved in tau pathology.
RPS6KB2 participates in key neuronal signaling cascades:
Key interacting partners include:
RPS6KB2 is implicated in:
RPS6KB2 is expressed throughout the brain with highest expression in:
Targeting RPS6KB2 signaling may offer therapeutic benefits: