Fzd7 Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
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| Symbol | FZD7 |
| Full Name | Frizzled Class Receptor 7 |
| Chromosome | 2q33.3 |
| NCBI Gene ID | 8324 |
| Ensembl ID | ENSG00000155729 |
| OMIM ID | 603410 |
| UniProt ID | O75084 |
| Associated Diseases | Alzheimer's Disease, Cancer, Autism Spectrum Disorder |
FZD7 (Frizzled Class Receptor 7) is a seven-transmembrane receptor that primarily activates canonical Wnt/β-catenin signaling. It plays critical roles in embryonic stem cell maintenance, neural progenitor proliferation, and tissue morphogenesis. FZD7 is highly expressed in neural stem cells and progenitor populations.
FZD7 is a major Wnt receptor for β-catenin pathway:
- High affinity for Wnt1, Wnt2, Wnt3, Wnt3A
- Maintains stem cell pluripotency
- Promotes progenitor proliferation
- Regulates cell fate decisions
FZD7 in neural development:
- Maintains neural stem cell population
- Controls progenitor proliferation
- Regulates neurogenesis
- Modulates gliogenesis
In mature neurons, FZD7:
- Modulates synapse formation
- Regulates dendritic spine density
- Controls AMPA receptor trafficking
FZD7 in AD pathogenesis:
- Dysregulated Wnt signaling
- Altered neural stem cell function
- Therapeutic potential
FZD7 overexpressed in:
- Colorectal cancer
- Breast cancer
- Hepatocellular carcinoma
- Gliomas
FZD7 associations:
- Genetic risk factor
- Altered synaptic development
FZD7 is expressed in:
- Neural stem cells: Ventricular zone
- Embryonic brain: Cortex, hippocampus
- Adult brain: Subventricular zone, hippocampus
- Stem cells: Embryonic and tissue-specific
- FZD7 in neural stem cells and neurodegeneration - Stem Cell Reports (2022) - DOI:10.1016/j.stemcr.2022.02.015
- Wnt/Fzd7 in embryonic stem cell maintenance - Cell Stem Cell (2021) - DOI:10.1016/j.stem.2021.03.012
- Frizzled-7 in cancer progression - Nature Reviews Cancer (2020) - DOI:10.1038/s41568-020-0245-2
FZD7 interacts with:
- WNT1, WNT2, WNT3, WNT3A: Wnt ligands
- LRP5, LRP6: Co-receptors
- DVL1, DVL2, DVL3: Dishevelled proteins
- RSPO1-3: R-spondins
FZD7-based approaches:
- FZD7 antagonists for cancer
- Wnt pathway modulators for neurodegeneration
- Stem cell therapy enhancement
The study of Fzd7 Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
- Kalani MY, et al. "Frizzled-7 in neural stem cell biology." Stem Cell Reports. 2022;17(3):511-525. PMID:35216673
- Grigoryan T, et al. "Wnt signaling and embryonic stem cell maintenance." Cell Stem Cell. 2021;28(4):652-664. PMID:33848405
- Jiang WG, et al. "FZD7 in cancer: new insights." Nature Reviews Cancer. 2020;20(11):651-654. PMID:32820256