| HNRNPQ | |
|---|---|
| Full Name | Heterogeneous Nuclear Ribonucleoprotein Q |
| Synonyms | HNRNPQ, SYNCRIP, NSAP1, GRY-RBP |
| Chromosomal Location | 6p21.1 |
| NCBI Gene ID | [10492](https://www.ncbi.nlm.nih.gov/gene/10492) |
| Ensembl ID | [ENSG00000121316](https://www.ensembl.org/Homo_sapiens/ENSG00000121316) |
| UniProt ID | [O60506](https://www.uniprot.org/uniprot/O60506) |
| OMIM ID | 607210 |
| Associated Diseases | [Amyotrophic Lateral Sclerosis](/diseases/amyotrophic-lateral-sclerosis), [Alzheimer's Disease](/diseases/alzheimers-disease), [Parkinson's Disease](/diseases/parkinsons-disease) |
TARDBP is a human gene whose product hNRNPQ** (Heterogeneous Nuclear Ribonucleoprotein Q), also known as SYNCRIP or NSAP1, is an RNA-binding protein involved in multiple aspects of RNA metabolism. HNRNPQ plays critical roles in post-transcriptional regulation of gene expression through its involvement in RNA splicing, transport, translation, and stability. Variants in TARDBP have been implicated in Amyotrophic Lateral Sclerosis (ALS), Alzheimer's Disease (AD), Parkinson's Disease (PD). This page covers the gene's normal function, disease associations, expression patterns, and key research findings relevant to neurodegeneration.
HNRNPQ (Heterogeneous Nuclear Ribonucleoprotein Q), also known as SYNCRIP or NSAP1, is an RNA-binding protein involved in multiple aspects of RNA metabolism. HNRNPQ plays critical roles in post-transcriptional regulation of gene expression through its involvement in RNA splicing, transport, translation, and stability.
The protein contains:
Key functions include:
HNRNPQ is implicated in amyotrophic lateral sclerosis through:
HNRNPQ is ubiquitously expressed with high levels in:
In the brain:
HNRNPQ is a potential therapeutic target:
For AD:
HNRNPQ interacts with: