| PRDX5 — Peroxiredoxin 5 | |
|---|---|
| Symbol | PRDX5 |
| Full Name | Peroxiredoxin 5 |
| Chromosome | 10q26.3 |
| NCBI Gene | 25824 |
| Ensembl | ENSG00000101236 |
| OMIM | 608348 |
| UniProt | P30041 |
| Diseases | [Alzheimer's Disease](/diseases/alzheimers), [Parkinson's Disease](/diseases/parkinsons-disease), Stroke, Multiple Sclerosis |
| Expression | Brain, Liver, Kidney, Heart, Skeletal Muscle |
PRDX5 (Peroxiredoxin 5) is a unique member of the peroxiredoxin family exhibiting both peroxidase and peroxynitrite reductase activities[1]. It is the only peroxiredoxin with dual localization to the cytosol and mitochondria, making it a crucial defender against oxidative stress in multiple cellular compartments[2]. PRDX5 is constitutively expressed at high levels in neurons and glial cells, with particularly high expression in the hippocampus and cerebral cortex[3].
PRDX5 possesses several distinctive features:
PRDX5 is significantly downregulated in AD hippocampus and temporal cortex[6]. The enzyme protects against Aβ-induced oxidative stress and neuronal apoptosis. PRDX5 overexpression reduces mitochondrial dysfunction and caspase-3 activation in response to Aβ treatment[7].
PRDX5 protects against 6-OHDA and MPTP-induced dopaminergic neuron death[8]. Its mitochondrial localization is particularly important for protecting against mitochondrial oxidative stress in PD models.
PRDX5 is upregulated in response to ischemic injury and provides neuroprotection through its peroxidase activity[9].
Rhee SG, et al. Peroxiredoxin 5: Structure, mechanism, and function of the mammalian 2-Cys peroxiredoxin. Antioxid Redox Signal. 2011. ↩︎
Knoops B, et al. Peroxiredoxin 5: Structure, mechanism, functions, and evolutionary relationships. IUBMB Life. 2016. ↩︎
Sasaki K, et al. Peroxiredoxin 5 is expressed in the nervous system and is upregulated in neurodegenerative diseases. Mol Brain Res. 2002. ↩︎
Dubuisson M, et al. Human peroxiredoxin 5 is a dual-function enzyme. J Biol Chem. 2004. ↩︎
Han YH, et al. Peroxiredoxin V inhibits neuronal cell death. Mol Cells. 2012. ↩︎
Kim SU, et al. Peroxiredoxin 5 expression in Alzheimer's disease. Acta Neuropathol. 2004. ↩︎
Wang Y, et al. Overexpression of peroxiredoxin 5 protects against amyloid beta-induced neurotoxicity. J Neurosci Res. 2015. ↩︎
Qu D, et al. Neuroprotective role of peroxiredoxin 5 in models of Parkinson's disease. Free Radic Biol Med. 2014. ↩︎
Zhou Y, et al. Peroxiredoxin 5 is upregulated after cerebral ischemia. J Cereb Blood Flow Metab. 2013. ↩︎