| TRPC1 — Transient Receptor Potential Cation Channel Subfamily C Member 1 | |
|---|---|
| Symbol | TRPC1 |
| Full Name | Transient Receptor Potential Cation Channel Subfamily C Member 1 |
| Chromosome | 3q23 |
| NCBI Gene | 7220 |
| Ensembl | ENSG00000113615 |
| OMIM | 602409 |
| UniProt | P48995 |
| Diseases | Alzheimer's Disease, Parkinson's Disease, Stroke |
| Expression | Ubiquitous - Brain, Heart, Skeletal muscle, Endothelium |
TRPC1 (Transient Receptor Potential Cation Channel Subfamily C Member 1) is the founding member of the TRPC (Canonical) subfamily of TRP channels. Located on chromosome 3q23, TRPC1 encodes a non-selective calcium-permeable cation channel that plays fundamental roles in cellular signaling, neuronal function, and vascular homeostasis [1][2].
TRPC1 is ubiquitously expressed and forms both homomeric and heteromeric channels with other TRPC family members. The channel is activated by receptor-operated mechanisms involving phospholipase C (PLC) and is critical for calcium influx in response to G-protein-coupled receptor (GPCR) and tyrosine kinase receptor activation [3][4].
The TRPC1 gene spans approximately 35 kb and consists of 13 exons. It encodes a protein of 793 amino acids with a molecular weight of approximately 90 kDa. The gene promoter contains response elements for various transcription factors, enabling tissue-specific expression [5].
TRPC1 is expressed throughout the nervous system:
TRPC1 functions as a non-selective cation channel with:
TRPC1 is activated through:
G-protein coupled receptors (GPCRs)
Tyrosine kinase receptors
Store-operated mechanisms
In neurons, TRPC1 contributes to:
TRPC1 is implicated in AD through:
Calcium Dysregulation
Synaptic Dysfunction
Neuronal Survival
In PD:
Dopaminergic Neuron Vulnerability
Oxidative Stress
Alpha-Synuclein Toxicity
TRPC1 plays roles in:
TRPC1 is a potential therapeutic target:
Modulators
Signaling Pathway Targets