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| Symbol | HTR3B |
| Full Name | 5-Hydroxytryptamine Receptor 3B |
| Chromosome | 11q23.1 |
| NCBI Gene | 3360 |
| OMIM | 604654 |
| Ensembl | ENSG00000136870 |
| UniProt | O95274 |
| Associated Diseases | Psychiatric disorders |
HTR3B (Cholinergic Receptor Nicotinic Alpha Subunit) is a gene encoding a protein that plays important roles in neuronal signaling and has been implicated in neurodegenerative diseases including Alzheimer's and Parkinson's disease.
The HTR3B gene encodes a critical subunit of nicotinic acetylcholine receptors (nAChRs), which are ligand-gated ion channels important for fast synaptic transmission in the central nervous system. These receptors are widely expressed in the brain and play roles in cognitive function, attention, and motor control.
Nicotinic acetylcholine receptors are pentameric ligand-gated ion channels composed of alpha and beta subunits. The HTR3B subunit contributes to receptor heterogeneity and influences receptor trafficking, conductance properties, and pharmacological sensitivity. Research has shown that variations in HTR3B are associated with nicotine dependence, and dysregulation of these receptors has been observed in neurodegenerative conditions.
HTR3B encodes the 5-HT3 receptor subunit B. The 5-HT3 receptor is the only ligand-gated ion channel in the serotonin receptor family. It plays important roles in fast synaptic transmission, particularly in the enteric nervous system and brain regions involved in emesis and mood.
HTR3B encodes the 5-HT3B subunit. Co-assembles with HTR3A to form functional receptors.
Expressed in brain and peripheral tissues.