| RAB11B — RAB11B, Member RAS Oncogene Family | |
|---|---|
| Symbol | RAB11B |
| Full Name | RAB11B, Member RAS Oncogene Family |
| Chromosome | 19p13.2 |
| NCBI Gene | 5876 |
| Ensembl | ENSG00000185236 |
| UniProt | Q9UQ90 |
| Diseases | [Parkinson's Disease](/diseases/parkinsons-disease), [Huntington's Disease](/diseases/huntingtons), Neurodevelopmental disorders |
| Expression | Brain, [Neurons](/entities/neurons), Neurosecretory cells |
RAB11B (RAB11B, Member RAS Oncogene Family) is a member of the RAB GTPase family, which regulates vesicular trafficking in eukaryotic cells. Located on chromosome 19p13.2, RAB11B plays critical roles in neuronal function, particularly in synaptic vesicle recycling, neurotransmitter release, and axonal transport[1]. It is closely related to RAB11A, with which it shares functional overlap but exhibits distinct tissue expression patterns.
RAB11B is a small GTPase that cycles between an active (GTP-bound) and inactive (GDP-bound) state. As a molecular switch, it regulates:
RAB11B is involved in the recycling of synaptic vesicles after neurotransmitter release. It controls the reformation of synaptic vesicles from endosomes, a critical process for maintaining neurotransmission[1:1].
RAB11B coordinates the movement of cargo vesicles along axons and dendrites, ensuring proper distribution of proteins and lipids to neuronal processes.
In neurosecretory cells, RAB11B regulates the trafficking of secretory granules, affecting neuropeptide release.
RAB11B participates in autophagy, specifically in the regulation of autophagosome formation and maturation. This is particularly relevant to neurodegenerative diseases where autophagy is often impaired.
RAB11B has been implicated in Parkinson's disease pathogenesis through its role in:
In HD, RAB11B dysfunction may contribute to:
RAB11B variants have been associated with intellectual disability and autism spectrum disorders, reflecting its critical role in neuronal development and synaptic function.
RAB11B is enriched in:
RAB11B interacts with several key neuronal proteins: