Kcnj15 Gene plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
Kcnj15 Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
.infobox-gene
!! colspan="2" style="background:#f8f9fa; text-align:center; font-weight:bold" | KCNJ15 - Potassium Inwardly Rectifying Channel Subfamily J Member 15
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! Chromosomal Location
| 21q22.12 |
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! NCBI Gene ID
! OMIM
! Ensembl ID
! UniProt
! Associated Diseases
| Alzheimer's disease risk, kidney disease |
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KCNJ15 encodes Kir4.2, an inwardly rectifying potassium channel. It is expressed in brain and kidney, and genetic variants have been associated with altered risk for Alzheimer's disease.
Alzheimer's disease risk, kidney disease
Expressed in brain, kidney, and pancreatic beta cells.
Kcnj15 Gene plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
The study of Kcnj15 Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
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[3]: Jentsch TJ. Neuronal KCNQ potassium channels: physiology and role in disease. Nat Rev Neurosci. 2000;1(1):21-30. PMID:11251309
[4]: Greka A, et al. KCNJ2/Kir2.1 channelopathy: from beds to bedside. Nat Rev Neurol. 2011;7(5):265-276. PMID:21487436
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[6]: Schulte U, et al. Mitochondrial KATP channel and its implication in cardiac protection. J Mol Cell Cardiol. 2012;52(2):404-409. PMID:22108176
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[8]: Brown BM, et al. Neuronal K+ channels and epilepsy. Novartis Found Symp. 2006;266:74-90. PMID:16720433