Homer3 — Homer Scaffold Protein 3 is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
| HOMER3 — Homer Scaffold Protein 3 | |
|---|---|
| Symbol | HOMER3 |
| Full Name | Homer Scaffold Protein 3 |
| Chromosome | 19p13.11 |
| NCBI Gene | 84524 |
| Ensembl | ENSG00000054884 |
| OMIM | 604730 |
| UniProt | Q9NZM1 |
| Diseases | Alzheimer's Disease, Parkinson's Disease, Schizophrenia |
| Expression | Brain (Cortex, Hippocampus, Cerebellum) |
HOMER3 is a gene located on chromosome 19p13.11 that encodes a member of the Homer family of postsynaptic density (PSD) scaffolding proteins. HOMER3 is primarily expressed in the brain and plays crucial roles in synaptic structure, function, and signaling.
HOMER3 participates in:
HOMER proteins contain:
HOMER3 specifically:
Alzheimer's Disease: HOMER3 expression is altered in AD brain. Changes may affect mGluR signaling and calcium homeostasis.
Parkinson's Disease: HOMER3 may play roles in dopaminergic synapse function.
Schizophrenia: HOMER3 genetic variants have been associated with schizophrenia risk.
The study of Homer3 — Homer Scaffold Protein 3 has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.