Gabarapl1 — Gaba Type A Receptor Associated Protein Like 1 is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
| GABARAPL1 — GABA Type A Receptor Associated Protein Like 1 | |
|---|---|
| Symbol | GABARAPL1 |
| Full Name | GABA Type A Receptor Associated Protein Like 1 |
| Chromosome | 12p13.2 |
| NCBI Gene | 23710 |
| Ensembl | ENSG00000139218 |
| OMIM | 607420 |
| UniProt | Q9Y4L5 |
| Diseases | Alzheimer's Disease, Parkinson's Disease, Autophagy Disorders |
| Expression | Brain, Heart, Kidney, Liver, Testis |
GABARAPL1 (GABA Type A Receptor Associated Protein Like 1) is a gene located on chromosome 12p13.2 that encodes a member of the ATG8 family of autophagy proteins. GABARAPL1 is involved in autophagy, intracellular trafficking, and may have additional functions unrelated to autophagy.
GABARAPL1 (also called GEC1, Golgi-Endoplasmic Reticulum protein 1):
Like other ATG8 proteins:
Alzheimer's Disease: GABARAPL1 expression is altered in AD brain. The protein may be involved in clearance of protein aggregates.
Parkinson's Disease: GABARAPL1 may participate in mitophagy and clearance of damaged mitochondria.
Huntington's Disease: GABARAPL1 may be involved in mutant huntingtin clearance.
The study of Gabarapl1 — Gaba Type A Receptor Associated Protein Like 1 has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.