Adra1B Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
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| Attribute | Value |
|---|---|
| Gene Symbol | ADRA1B |
| Full Name | Alpha-1B Adrenergic Receptor |
| Chromosomal Location | 5q23.3 |
| NCBI Gene ID | 147 |
| Ensembl ID | ENSG00000170175 |
| UniProt ID | P35368 |
| Gene Family | Adrenergic receptors (GPCR) |
| Protein Class | G protein-coupled receptor |
| Expression | Smooth muscle, brain, heart |
The ADRA1B gene encodes the alpha-1B adrenergic receptor (α1B-AR), a G protein-coupled receptor that mediates the effects of epinephrine and norepinephrine on smooth muscle contraction, cardiac function, and neuronal signaling. This receptor plays important roles in cardiovascular regulation, blood pressure control, and may be relevant to neurodegenerative diseases.
The ADRA1B gene is located on chromosome 5q23.3 and encodes a 515-amino acid protein. The receptor contains seven transmembrane domains typical of GPCRs and couples primarily to Gq proteins, activating phospholipase C signaling pathways.
α1B-adrenergic receptors are expressed in:
| Drug | Type | Clinical Use |
|---|---|---|
| Prazosin | Antagonist | Hypertension, PTSD |
| Terazosin | Antagonist | BPH |
| Doxazosin | Antagonist | Hypertension, BPH |
| Tamsulosin | Antagonist | BPH (selective) |
The study of Adra1B Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.