The TRPV1 (Transient Receptor Potential Vanilloid 1) gene encodes a non-selective cation channel belonging to the TRP (Transient Receptor Potential) superfamily. TRPV1 is best known as the receptor for capsaicin (the active component in chili peppers) and noxious heat (>43°C). It plays a crucial role in pain perception, neuroinflammation, and thermosensation. In the brain, TRPV1 is expressed in various regions including the hippocampus, basal ganglia, and cortex. Emerging research suggests TRPV1 dysfunction may contribute to neurodegenerative processes in Parkinson's disease and other disorders. The channel's involvement in calcium signaling and its distribution in dopaminergic neurons make it a potential therapeutic target.
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| Symbol | TRPV1 |
| Full Name | Transient Receptor Potential Cation Channel Subfamily V Member 1 |
| Chromosome | 17p13.2 |
| NCBI Gene | 7442 |
| OMIM | 602077 |
| Ensembl | ENSG00000196584 |
| UniProt | Q9Y5Q1 |
| Associated Diseases | Pain, neuroinflammation, Parkinson's disease |
TRPV1 is a gene encoding a transient receptor potential (TRP) channel that plays important roles in sensory transduction and has been implicated in neurodegenerative diseases.
The TRPV1 gene encodes a non-selective cation channel belonging to the TRP superfamily. These channels are activated by various stimuli including temperature, chemicals, and mechanical force, and contribute to cellular calcium signaling.
TRP channels are widely expressed in the nervous system and participate in sensory perception, neuroprotection, and disease processes. The TRPV1 channel has been studied in the context of oxidative stress, neuroinflammation, and neurodegenerative conditions including Alzheimer's and Parkinson's disease.
TRPV1 is a capsaicin-activated ion channel that responds to heat and pain stimuli. Involved in neuroinflammation and pain perception.
High expression in sensory neurons and dorsal root ganglion.