CALCR (Calcitonin Receptor) is a G protein-coupled receptor that responds to calcitonin and related peptides. It plays important roles in calcium homeostasis and has emerging roles in nervous system function.
CALCR is a class B GPCR:
Migraine: Calcitonin gene-related peptide (CGRP) receptor components are targets for migraine treatment [1].
Alzheimer's Disease: CALCR expression is altered in AD brains [2].
Pain: The receptor is involved in pain signaling pathways [3].