Ryr3 Ryanodine Receptor 3 is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
| Ryanodine Receptor 3 | |
|---|---|
| Gene Symbol | RYR3 |
| Full Name | Ryanodine Receptor 3 |
| Chromosome | 15q13.3 |
| NCBI Gene ID | 6263 |
| OMIM | 180903 |
| Ensembl ID | ENSG00000198853 |
| UniProt ID | Q15413 |
| Associated Diseases | Alzheimer's Disease, Bipolar Disorder, Epilepsy |
RYR3 is a gene that encodes a protein involved in calcium release and neuronal signaling. This gene is implicated in neurodegenerative diseases and represents a potential therapeutic target.
RYR3 is the third ryanodine receptor isoform with widespread but lower expression. It may function as a calcium leak channel and modulate calcium signaling[^1].
RYR3 performs modulatory functions:
RYR3 implicated in AD:
RYR3 is expressed in:
The study of Ryr3 Ryanodine Receptor 3 has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.