Pick1 Protein Interacting With C Kinase 1 is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
| Protein Interacting With C Kinase 1 | |
|---|---|
| Gene Symbol | PICK1 |
| Full Name | Protein Interacting With C Kinase 1 |
| Chromosome | 22q13.33 |
| NCBI Gene ID | 9444 |
| OMIM | 605600 |
| Ensembl ID | ENSG00000100168 |
| UniProt ID | Q9YEP4 |
| Associated Diseases | Alzheimer's Disease, Parkinson's Disease, Schizophrenia |
PICK1 is a gene that encodes a protein involved in protein sorting and synaptic plasticity. This gene is implicated in neurodegenerative diseases and represents a potential therapeutic target.
PICK1 is a PDZ domain-containing protein that interacts with protein kinase C (PKC) and various membrane proteins including AMPA receptors. It is involved in synaptic plasticity and receptor trafficking[^1].
PICK1 performs synaptic functions:
PICK1 implicated in AD:
PICK1 is expressed in:
The study of Pick1 Protein Interacting With C Kinase 1 has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.