Official Symbol: GSTP1
Official Full Name: Glutathione S-Transferase Pi 1
Gene Type: Protein Coding
Location: Chromosome 11q13.2
NCBI Gene ID: 2950
Ensembl ID: ENSG00000084207
UniProt ID: P09211
Glutathione S-Transferase Pi 1 (GSTP1) is a member of the GST family of enzymes that catalyze the conjugation of glutathione (GSH) to various electrophilic compounds. This enzyme plays important roles in detoxification, antioxidant defense, and regulation of cell signaling pathways. In the brain, GSTP1 is expressed in neurons and glia and contributes to neuroprotection against oxidative stress and xenobiotics.
- Conjugation: Catalyzes GSH conjugation to toxins
- Detoxification: Protects against electrophilic compounds
- Isomerase Activity: prostaglandin synthase activity
- JNK Sequestration: Binds and inhibits JNK signaling
- ASK1 Interaction: Modulates apoptosis signaling
- TNF Signaling: Interacts with TNF receptor
- ROS Detoxification: Part of antioxidant defense
- DNA Protection: Prevents oxidative DNA damage
- Lipid Peroxidation: Reduces lipid peroxidation products
- Expression Changes: GSTP1 altered in AD brain
- Aβ Interaction: Binds to amyloid plaques
- Therapeutic Target: GSTP1 modulators
- Dopamine Metabolism: Protects against dopamine oxidation
- Genetic Variants: GSTP1 polymorphisms affect PD risk
- Neuroprotection: Guards against environmental toxins
- Oxidative Stress: GSTP1 in ALS models
- Therapeutic Potential: Antioxidant approaches
- Chemoresistance: GSTP1 in drug resistance
- Therapeutic Target: GST inhibitors
- Neurons: Expressed in various neuronal populations
- Astrocytes: Astrocytic expression
- Oligodendrocytes: Present in myelin-forming cells
- Nrf2: Transcriptionally regulated
- Stress Response: Induced by oxidative stress
- Townsend DM et al., GSTP1 in cell signaling (2007)
- Clements J et al., GSTP1 in the brain (2010)
- Johnson JD et al., GSTP1 and AD (2003)
- Saadat M et al., GSTP1 polymorphisms in PD (2006)
- van der Westhuizen FH et al., GSTP1 and neurodegeneration (2005)
- Hayes JD et al., Glutathione transferases (2005)
- Aldred S et al., GSTP1 in aging brain (2011)
- Tew KD et al., GSTP1 as therapeutic target (2011)