| ELP4 — Elongator Acetyltransferase Complex Subunit 4 | |
|---|---|
| Symbol | ELP4 |
| Full Name | Elongator Acetyltransferase Complex Subunit 4 |
| Chromosome | 11p13 |
| NCBI Gene | 23525 |
| Ensembl | ENSG00000109099 |
| UniProt | Q9BYH4 |
| Diseases | Amyotrophic Lateral Sclerosis, Epilepsy |
| Expression | Brain, Testis, Spinal cord motor neurons |
ELP4 (Elongator Acetyltransferase Complex Subunit 4) is a gene located on chromosome 11p13 that encodes a subunit of the Elongator complex. ELP4 is the tRNA-binding subunit of the complex, essential for tRNA modification at the wobble position. Genetic variants in ELP4 have been linked to epilepsy and amyotrophic lateral sclerosis (ALS).
The Elongator complex (ELP1-ELP6) is a conserved multisubunit complex involved in transcriptional elongation and tRNA modification. ELP4 serves as the tRNA-binding component, forming a functional subcomplex with ELP5 and ELP6 required for mcm5U modification of tRNA wobble positions.
The ELP4 gene spans approximately 25 kb and consists of 14 exons on chromosome 11p13.
ELP4 is a 46-kDa protein with:
Page created: 2026-03-08