| WNT5A | |
|---|---|
| Full Name | Wnt Family Member 5A |
| Chromosomal Location | 3p14.3 |
| NCBI Gene ID | [7476](https://www.ncbi.nlm.nih.gov/gene/7476) |
| OMIM | [164975](https://www.omim.org/entry/164975) |
| Ensembl ID | ENSG00000114270 |
| UniProt | [Q9H0J5](https://www.uniprot.org/uniprot/Q9H0J5) |
| Associated Diseases | Alzheimer's Disease, Parkinson's Disease, Autism Spectrum Disorder, Robinow Syndrome |
WNT5B is a human gene whose product wNT5A encodes a member of the Wnt family of secreted signaling molecules that play critical roles in embryonic development, cell polarity, migration, and tissue patterning. WNT5A signals through both canonical (β-catenin-dependent) and non-canonical (β-catenin-independent) pathways, including the planar cell polarity (PCP) and Wnt/Ca²⁺ pathways. Variants in WNT5B have been implicated in Neurodegenerative Diseases, Neurodevelopmental Disorders. This page covers the gene's normal function, disease associations, expression patterns, and key research findings relevant to neurodegeneration.
WNT5A encodes a member of the Wnt family of secreted signaling molecules that play critical roles in embryonic development, cell polarity, migration, and tissue patterning. WNT5A signals through both canonical (β-catenin-dependent) and non-canonical (β-catenin-independent) pathways, including the planar cell polarity (PCP) and Wnt/Ca²⁺ pathways.
In the nervous system, WNT5A regulates:
WNT5A interacts with multiple receptors including Frizzled (FZD) receptors, ROR1, ROR2, and Ryk to activate downstream signaling cascades including DVL, RAC, JNK, and PKC pathways.
Alzheimer's Disease:
Parkinson's Disease:
Autism Spectrum Disorder:
Robinow Syndrome:
WNT5A exhibits region-specific expression in the brain:
During development, WNT5A is expressed in the cortical marginal zone, intermediate zone, and subventricular zone, regulating neuronal migration.