Rgs14 Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
RGS14 encodes Regulator of G Protein Signaling 14, a scaffold protein that integrates G protein and MAPK signaling in hippocampal learning and memory.
| Attribute | Value |
|---|---|
| Gene Symbol | RGS14 |
| Full Name | Regulator of G Protein Signaling 14 |
| Chromosomal Location | 5q23.2 |
| NCBI Gene ID | 10536 |
| OMIM | 607497 |
| Ensembl ID | ENSG00000172322 |
| UniProt ID | Q9Y2H9 |
RGS14 is a multifunctional scaffold protein with an N-terminal RGS domain, PDZ domain, and C-terminal GoLoco motif. It integrates Gαi/o signaling with MAPK/ERK pathways by binding activated Ras and Raf. Critical for hippocampal learning and memory, particularly for spatial navigation and object recognition. Regulates dendritic spine morphology and synaptic plasticity in CA2 pyramidal neurons. Also modulates platelet activation and immune cell function.
Alzheimer's Disease: Impaired hippocampal plasticity; cognitive deficits.
Schizophrenia: Altered synaptic function in hippocampus.
Intellectual Disability: Developmental abnormalities.
Migraine: Vascular signaling dysregulation.
RGS14 Gene is a gene/protein involved in cellular signaling and neuronal function. This page covers its molecular characteristics, biological function, role in disease, and therapeutic implications.
High expression in hippocampus (CA1/CA2), cortex, and cerebellum. Specifically enriched in dendritic spines of pyramidal neurons. Also expressed in platelets and immune cells.
RGS14 targeting approaches:
The study of Rgs14 Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.