Rab38 Gene plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
Rab38 Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
| RAB38, Member RAS Oncogene Family | |
|---|---|
| Gene Symbol | RAB38 |
| Full Name | RAB38, Member RAS Oncogene Family |
| Chromosome | 11q14.2 |
| NCBI Gene ID | 28284 |
| OMIM | 606436 |
| Ensembl ID | ENSG00000123892 |
| UniProt ID | O14964 |
| Associated Diseases | Parkinson's Disease, Hermansky-Pudlak Syndrome, Cancer, Pigmentation Disorders |
RAB38 encodes a small GTPase involved in intracellular vesicle trafficking, particularly melanosome and lysosome-related organelle function. RAB38 regulates trafficking to lysosome-related organelles and is important for melanosome biogenesis. RAB38 and its partner RAB32 regulate mitochondrial quality control and have been implicated in Parkinson's disease. RAB38 variants may affect dopaminergic neuron survival through altered autophagy and lysosomal function.
Expressed in brain (especially basal ganglia), melanocytes, platelets, and lung. Higher expression in pigmented tissues.
| Disease | Mechanism |
|---|---|
| Parkinson's Disease | |
| Hermansky-Pudlak Syndrome | |
| Cancer | |
| Pigmentation Disorders |
| Partner | Interaction Type | Pathway |
|---|
No clinical trials directly targeting this gene are currently registered for neurodegenerative diseases.
Rab38 Gene plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
The study of Rab38 Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.