| SPG26 | |
|---|---|
| Full Name | SPG26 (Spastic Paraplegia 26 / BAAT) |
| Chromosomal Location | 12q21.31 |
| NCBI Gene ID | 84069 |
| OMIM | 609673 |
| UniProt ID | Q8N6K6 |
| Category | Metabolic Enzyme |
The SPG26 gene encodes SPG26 (Spastic Paraplegia 26 / BAAT), a metabolic enzyme protein. It is involved in various cellular processes relevant to neurodegeneration.
SPG26 encodes the enzyme BAAT (bile acid CoA:amino acid N-acyltransferase), which is involved in bile acid metabolism. While its role in neurodegeneration is not fully characterized, BAAT is expressed in various tissues including the brain. It plays roles in bile acid metabolism, amino acid conjugation, and lipid homeostasis.
| Disease | Role in Disease |
|---|---|
| Hereditary Spastic Paraplegia 26 | Autosomal recessive HSP with intellectual disability and peripheral neuropathy |