Fancm Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
| Fanconi Anemia Group M | |
|---|---|
| Gene Symbol | FANCM |
| Full Name | FA complementation group M |
| Chromosome | 7q22.3 |
| NCBI Gene ID | 57697 |
| OMIM | 609644 |
| Ensembl ID | ENSG00000187240 |
| UniProt ID | Q8IWA5 |
| Associated Diseases | Fanconi Anemia, Breast Cancer, Parkinson's Disease |
FANCM encodes a DNA translocase that plays a critical role in the Fanconi anemia (FA) pathway, which is essential for DNA interstrand crosslink (ICL) repair and maintenance of genomic stability. It is one of the key proteins that initiates the FA repair cascade upon DNA damage detection.
FANCM is a DNA translocase and a key component of the Fanconi anemia (FA) pathway. It recognizes DNA damage and initiates the FA repair cascade.
Key functions include:
FANCM is expressed ubiquitously:
The study of Fancm Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
FANCM is a DNA translocase that initiates the FA pathway by detecting DNA damage and recruiting the FA core complex.