Nptxr — Neuronal Pentraxin Receptor is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
NPTXR — Neuronal Pentraxin Receptor is involved in neuronal signaling and synaptic function.
Neuronal Pentraxin Receptor (NPTXR) is a membrane protein that serves as the primary receptor for the neuronal pentraxin family, including NPTX1 and NPTX2. It is a member of the pentraxin family but functions as a cell surface receptor rather than a secreted protein.
NPTXR is enriched at excitatory synapses and plays a critical role in:
The receptor contains an extracellular domain that binds neuronal pentraxins and a cytoplasmic tail that interacts with synaptic proteins, including components of the vesicle release machinery.
NPTXR expression is altered in Alzheimer's disease, particularly in brain regions showing amyloid pathology. Changes in NPTXR may contribute to:
Altered NPTXR expression has been implicated in the synaptic remodeling that occurs during epileptogenesis. The receptor may play a role in the aberrant sprouting and synapse formation observed in epileptic tissue.
NPTXR shows high expression in:
The receptor is localized to both pre- and postsynaptic membranes at excitatory synapses.
The study of Nptxr — Neuronal Pentraxin Receptor has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.