Adam22 — Adam Metallopeptidase Domain 22 is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
| ADAM Metallopeptidase Domain 22 | |
|---|---|
| Gene Symbol | ADAM22 |
| Full Name | ADAM metallopeptidase domain 22 |
| Chromosome | 7q21.2 |
| NCBI Gene ID | 5365 |
| OMIM | 605283 |
| Ensembl ID | ENSG00000010704 |
| UniProt ID | Q9P121 |
| Associated Diseases | Epilepsy, Alzheimer's Disease, Autism Spectrum Disorder |
The ADAM22 gene encodes a member of the ADAM family involved in synaptic function.
ADAM22 (A Disintegrin And Metalloproteinase domain 22) is a membrane protein that serves as a receptor for LGI1. Unlike many ADAM family members, ADAM22 is catalytically inactive and functions primarily as a cell adhesion molecule.
Key functions include:
ADAM22 is expressed in:
ADAM22 is a critical synaptic receptor linking LGI1 to synaptic function and neurological disease.
The study of Adam22 — Adam Metallopeptidase Domain 22 has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.