.infobox .infobox-gene {
background-color: #f8f9fa;
border: 1px solid #ddd;
padding: 10px;
width: 300px;
font-size: 0.9em;
}
.infobox .infobox-gene .gene-symbol {
font-weight: bold;
font-size: 1.2em;
color: #2c5282;
}
.infobox .infobox-gene .gene-name {
font-style: italic;
margin-bottom: 10px;
}
.infobox .infobox-gene table {
width: 100%;
border-collapse: collapse;
}
.infobox .infobox-gene td {
padding: 4px;
vertical-align: top;
}
.infobox .infobox-gene td.label {
font-weight: bold;
width: 40%;
color: #555;
}
.infobox .infobox-gene td.value {
width: 60%;
}
.infobox .infobox-gene a {
color: #0066cc;
text-decoration: none;
}
.infobox .infobox-gene a:hover {
text-decoration: underline;
}
| Symbol | EFNB2 |
| Full Name | Ephrin B2 |
| Chromosome | 13q33.3 |
| NCBI Gene | 1948 |
| OMIM | 600530 |
| Ensembl | ENSG00000145088 |
| UniProt | P52799 |
| Associated Diseases | Alzheimer's disease, vascular development |
EFNB2 (Ephrin B2) is a transmembrane ligand for EPHB receptors that mediates cell-cell communication and regulates synaptic plasticity. As an ephrin family member, EFNB2 plays crucial roles in neural development, synaptic function, and cellular signaling. Altered EFNB2 expression has been implicated in neurodegenerative diseases, particularly Alzheimer's disease and Parkinson's disease.
EFNB2 is a key ephrin-B ligand that binds EPHB receptors. It regulates synaptic plasticity, neurovascular coupling, and is implicated in AD pathogenesis. Important for blood-brain barrier function.
High expression in hippocampus, cortex, and vascular endothelium.