| XRCC2 — X-Ray Repair Cross-Complementing 2 | |
|---|---|
| Symbol | XRCC2 |
| Full Name | X-Ray Repair Cross-Complementing 2 |
| Chromosome | 7q36.1 |
| NCBI Gene | 7516 |
| UniProt | O43544 |
| Diseases | Breast Cancer, Ovarian Cancer, Neurodegeneration |
| Expression | Ubiquitous, Brain, Testis |
Xrcc2 X Ray Repair Cross Complementing 2 is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
XRCC2 (X-Ray Repair Cross-Complementing 2) is a gene located on chromosome 7q36.1 that encodes a protein essential for homologous recombination repair of DNA double-strand breaks[1]. The gene is catalogued as NCBI Gene ID 7516.
XRCC2 is a member of the RAD51 paralog family, which plays critical roles in maintaining genomic stability[2].
The XRCC2 gene encodes a protein involved in homologous recombination (HR), a high-fidelity DNA repair pathway.
XRCC2 functions in the RAD51-dependent homologous recombination pathway:
XRCC2 interacts with:
XRCC2 polymorphisms are associated with increased cancer risk:
DNA repair defects in neurons lead to:
XRCC2 (X-ray repair cross-complementing 2) is a 280 amino acid protein belonging to the RecA/RAD51 superfamily[1:1]. Unlike RAD51, XRCC2 lacks strand invasion activity but serves as a critical cofactor for RAD51-mediated homologous recombination.
XRCC2 forms a stable complex with RAD51C, known as the CX3 complex. This complex:
In response to DNA double-strand breaks:
Neurons face unique challenges:
Studies show XRCC2 expression is altered in:
Strategies under investigation:
XRCC2 knockout mice show:
Neuron-specific XRCC2 deletion leads to:
The study of Xrcc2 X Ray Repair Cross Complementing 2 has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.