Adcy7 — Adenylate Cyclase 7 is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
| Adenylate Cyclase 7 | |
|---|---|
| Gene Symbol | ADCY7 |
| Full Name | Adenylate cyclase 7 |
| Chromosome | 16q12.1 |
| NCBI Gene ID | 114 |
| OMIM | |
| Ensembl ID | ENSG00000121285 |
| UniProt ID | P51828 |
| Associated Diseases | Alzheimer's Disease, ALS |
ADCY7 (Adenylate Cyclase 7) is a member of the adenylate cyclase family that produces cyclic AMP (cAMP) in response to hormonal and neurotransmitter signaling. ADCY7 is highly expressed in immune cells and brain tissue, where it regulates immune response, cytokine production, and neuronal signaling. In the nervous system, ADCY7 participates in synaptic plasticity and memory formation. Altered ADCY7 expression and activity are observed in neurodegenerative diseases and psychiatric disorders, making it a potential therapeutic target.
ADCY7 encodes adenylate cyclase 7, a membrane-bound enzyme that produces cAMP. It is expressed in various tissues including brain and immune cells. ADCY7 is involved in immune response and neuronal signaling.
Expressed in brain and immune system. Important for cAMP production in various cell types.
| Disease | Variants | Inheritance | Mechanism |
|---|---|---|---|
| Alzheimer's Disease | Risk variants | Complex | cAMP signaling dysregulation |
| ALS | Variants | Complex | Motor neuron dysfunction |
The study of Adcy7 — Adenylate Cyclase 7 has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.