Ppp2Ca is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
| Protein Phosphatase 2 Catalytic Subunit Alpha | |
|---|---|
| Gene Symbol | PPP2CA |
| Full Name | Protein phosphatase 2 catalytic subunit alpha |
| Chromosome | 5q31.1 |
| NCBI Gene ID | 5515 |
| OMIM | 176915 |
| Ensembl ID | ENSG00000141837 |
| UniProt ID | P67775 |
| Associated Diseases | Alzheimer's Disease, Parkinson's Disease, Cancer, Intellectual Disability |
PPP2CA encodes the alpha isoform of protein phosphatase 2A (PP2A), a major serine/threonine phosphatase that regulates:
PP2A accounts for a large proportion of phosphatase activity in the brain and is critical for neuronal function.
PPP2CA is ubiquitously expressed with high levels in brain. PP2A exists as a heterotrimeric enzyme with regulatory B subunits that determine substrate specificity.
| Disease | Mechanism |
|---|---|
| Alzheimer's Disease | Tau hyperphosphorylation, impaired dephosphorylation |
| Parkinson's Disease | Alpha-synuclein phosphorylation |
| Cancer | Cell transformation |
| Intellectual Disability | Developmental defects |
PP2A activators are being developed for:
The study of Ppp2Ca has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
This section provides background information on the gene/protein and its role in the nervous system.
This overview section needs to be expanded with relevant scientific information from peer-reviewed sources.