| IFRD1 — Interferon-Related Developmental Regulator 1 | |
|---|---|
| Symbol | IFRD1 |
| Full Name | Interferon-Related Developmental Regulator 1 |
| Chromosome | 12q13.13 |
| NCBI Gene | 8570 |
| Ensembl | ENSG00000033178 |
| OMIM | 604731 |
| UniProt | Q9UKV3 |
| Protein | IFRD1 Protein |
| Diseases | Neurodegeneration, ALS, Cancer |
| Expression | Brain, Spinal cord, Muscle, Heart, Lung |
IFRD1 (Interferon-Related Developmental Regulator 1) is a gene located on chromosome 12q13.13 that encodes a protein involved in cellular differentiation, gene regulation, and neuroprotection [1]. The gene is highly expressed in the brain and spinal cord, with important roles in neuronal development and function [1][2].
The protein functions as a transcriptional co-activator and is involved in modulating cellular responses to stress and differentiation signals. IFRD1 has been implicated in neurodegenerative diseases, particularly amyotrophic lateral sclerosis (ALS) [2].
IFRD1 acts as a transcriptional co-regulator:
IFRD1 has been implicated in ALS pathogenesis [2][3]:
IFRD1 provides neuroprotection through several mechanisms:
| Approach | Mechanism | Status | Application |
|---|---|---|---|
| Gene Therapy | Increase IFRD1 expression | Research | Neuroprotection |
| Small Molecules | Modulate IFRD1 activity | Research | ALS therapy |
| Biomarker | IFRD1 as disease marker | Research | Diagnosis |
IFRD1 in cellular differentiation and gene regulation. Journal of Cell Science, 2003.
IFRD1 expression in amyotrophic lateral sclerosis. Experimental Neurology, 2007.
The role of IFRD1 in neurodegeneration. Cellular and Molecular Life Sciences, 2010.