Dync1I1 — Cytoplasmic Dynein 1 Intermediate Chain 1 is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
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| Gene Symbol | DYNC1I1 |
| Full Name | Cytoplasmic Dynein 1 Intermediate Chain 1 |
| Chromosomal Location | 7p21.1 |
| NCBI Gene ID | 1780 |
| OMIM | 617305 |
| Ensembl ID | ENSG00000111595 |
| UniProt ID | Q13418 |
| Associated Diseases | AD, PD, ALS, Charcot-Marie-Tooth |
Cytoplasmic Dynein 1 Intermediate Chain 1 is a subunit of the dynein motor complex, which transports cargo along microtubules toward the minus end. DYNC1I1 is essential for retrograde axonal transport, transporting signaling endosomes, synaptic components, and aggregates from distal axons back to cell bodies. Mutations in dynein components cause neurodegenerative diseases including Charcot-Marie-Tooth disease and ALS. Dynein dysfunction leads to impaired autophagic clearance of protein aggregates in neurodegenerative diseases.
The DYNC1I1 gene encodes the Cytoplasmic Dynein 1 Intermediate Chain 1, a protein involved in synaptic function, axonal transport, and neuronal signaling. This protein plays critical roles in maintaining neuronal health and function through its involvement in intracellular trafficking and signal transduction pathways.
Dysfunction or altered expression of DYNC1I1 has been associated with several neurodegenerative diseases:
DYNC1I1 is expressed in various brain regions, with high expression in:
The study of Dync1I1 — Cytoplasmic Dynein 1 Intermediate Chain 1 has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.