Yes1 — Proto Oncogene Tyrosine Protein Kinase Yes1 is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
Yes1 (Proto-Oncogene Tyrosine-Protein Kinase Yes1) is a member of the Src family of non-receptor tyrosine kinases (SFKs). It is a 60 kDa non-receptor tyrosine kinase that is widely expressed in tissues including brain, lung, and testis. Yes1 participates in signaling pathways controlling cell proliferation, differentiation, and epithelial-mesenchymal transition.
| Protein Name | Proto-Oncogene Tyrosine-Protein Kinase Yes1 |
| Gene | YES1 |
| UniProt ID | P42681 |
| Molecular Weight | 60 kDa |
| Subcellular Localization | Plasma membrane, Cytoplasm |
| Protein Family | Src family non-receptor tyrosine kinases |
The Yes1 protein is a member of the Src family of non-receptor tyrosine kinases (SFKs). The structure consists of:
Yes1 is a non-receptor tyrosine kinase that regulates multiple signaling pathways:
Dysregulated Yes1 activity contributes to:
Yes1-targeted therapies include:
The study of Yes1 — Proto Oncogene Tyrosine Protein Kinase Yes1 has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.