Src Protein (Src Proto Oncogene) plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
Src Protein (Src Proto Oncogene) is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
.infobox-protein
!! colspan="2" style="background:#f8f9fa; text-align:center; font-weight:bold" | SRC Protein (SRC Proto-Oncogene)
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! Gene
! UniProt
! PDB Structures
| 1H3R, 2H8H, 4K11, 6ATE |
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! Molecular Weight
| ~60 kDa |
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! Subcellular Localization
| Membrane, cytoskeleton |
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! Protein Family
| Src Family Tyrosine Kinase |
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SRC is the prototypical member of the Src family of tyrosine kinases. It has an N-terminal myristoylation site, SH3, SH2, and kinase domains with a C-terminal regulatory tail.
SRC regulates cell growth, differentiation, adhesion, and survival. It is involved in receptor tyrosine kinase signaling, integrin signaling, and cytoskeletal organization. In neurons, SRC regulates synaptic transmission.
SRC is activated in AD and contributes to synaptic dysfunction through NMDA receptor phosphorylation. It may also regulate amyloid precursor protein processing. SRC inhibitors show neuroprotective effects in models.
SRC inhibitors have been developed for cancer. Dasatinib has been tested in AD models. Challenges include achieving brain penetration and avoiding peripheral toxicity.
Src Protein (Src Proto Oncogene) plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
The study of Src Protein (Src Proto Oncogene) has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.