| LRP2 Protein (Megalin) | |
|---|---|
| Name | Low Density Lipoprotein Receptor-Related Protein 2 |
| UniProt | P98164 |
| Gene | LRP2 |
| Molecular Weight | ~600 kDa |
| Length | 4,630 amino acids |
| Cellular Location | Plasma membrane, Apical surface |
| Expression | Kidney, Brain, Epithelium, Choroid plexus |
| Aliases | Megalin, GP330 |
Lrp2 Protein (Megalin) is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
LRP2, also known as Megalin, is one of the largest known cell surface receptors. It is a multi-ligand scavenger receptor expressed in epithelial cells throughout the body, with particularly high expression in kidney proximal tubules and the choroid plexus of the brain.
Megalin contains:
LRP2/Megalin is involved in:
The study of Lrp2 Protein (Megalin) has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
[1] Farber, E. et al. (2009). Megalin in the choroid plexus. JCI, 119(8), 2143-2154.