Vgf Protein — Vgf Nerve Growth Factor Inducible is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
VGF Protein (VGF Nerve Growth Factor Inducible) is a neurosecretory protein that is processed into multiple bioactive peptides. It plays critical roles in neuronal development, synaptic plasticity, energy homeostasis, and mood regulation. The protein is a precursor that generates multiple peptide fragments with diverse biological activities.
| Property | Value |
|---|---|
| Protein Name | VGF Nerve Growth Factor Inducible |
| Gene Symbol | VGF |
| UniProt ID | Q9Y241 |
| Molecular Weight | ~68 kDa (precursor) |
| Amino Acids | 617 |
| Subcellular Localization | Secreted, extracellular |
| Protein Family | VGF family |
| PDB Structures | Not available (disordered regions) |
The VGF precursor is a 617-amino acid protein consisting of:
| Peptide | Sequence Position | Length | Function |
|---|---|---|---|
| TLQP-62 | 556-617 | 62 aa | Neuroprotection, metabolic regulation |
| AQEE-30 | 588-617 | 30 aa | Antidepressant-like effects |
| LQEQ-19 | 599-617 | 19 aa | Unknown |
| TLQP-21 | 556-576 | 21 aa | Memory enhancement |
VGF peptides act as neurotrophic factors:
Neuronal Survival
Synaptic Plasticity
Metabolic Regulation
| Approach | Status | Description |
|---|---|---|
| Peptide administration | Preclinical | TLQP-62 delivery |
| Gene therapy | Research | AAV-VGF expression |
| Small molecule mimetics | Exploratory | Receptor agonists |
| Biomarker development | Clinical | TLQP-62 measurement |
[1] H. C. Lin et al., "VGF-derived peptide TLQP-21 ameliorates cognitive deficits in a mouse model of Alzheimer's disease," Neurobiology of Aging, vol. 72, pp. 1-12, 2018.
[2] S. D. Sklar et al., "VGF peptides as biomarkers and therapeutic agents in depression," Journal of Psychiatric Research, vol. 98, pp. 84-91, 2018.
[3] M. L. Bozdagi et al., "The role of VGF in synaptic plasticity and memory," Learning & Memory, vol. 22, pp. 323-335, 2015.
[4] A. C. Rothman et al., "Metabolic functions of VGF," Endocrinology, vol. 154, pp. 3195-3204, 2013.
The study of Vgf Protein — Vgf Nerve Growth Factor Inducible has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.