Timm8A Protein plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
Timm8A Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
TIMM8A (Translocase of Inner Mitochondrial Membrane Subunit 8A) is a small mitochondrial intermembrane space chaperone protein that facilitates the import of nuclear-encoded proteins into the mitochondria. It partners with TIMM13 to form a heterohexameric complex that guides hydrophobic proteins across the intermembrane space.
| Attribute | Value |
|---|---|
| Protein Name | TIMM8A |
| Gene | TIMM8A |
| UniProt ID | O60220 |
| Molecular Weight | ~11 kDa |
| Subcellular Localization | Mitochondrial intermembrane space |
| Protein Family | Small TIM family |
| Substrate Category | Examples |
|---|---|
| Mitochondrial Carriers | SLC25A12, SLC25A13, SLC25A30 |
| Iron-Sulfur Cluster Proteins | ISCU, FXN |
| Inner Membrane Proteins | Tim17, Tim22 |
| Strategy | Compound | Status |
|---|---|---|
| Gene Therapy | AAV-TIMM8A | Preclinical |
| Small Molecule Chaperones | Synthetic chaperones | Research |
| Antioxidants | CoQ10, MitoQ | Experimental |
Koehler CM, et al. (1999). "The small Tim proteins facilitate the import of carrier proteins into mitochondria." Nature. PMID:10517498
Herrmann JM, et al. (2013). "Biogenesis of the mitochondrial intermembrane space." Biochim Biophys Acta. PMID:23603797
Deschauer M, et al. (2004). "A splice site mutation in TIMM8A causing isolated deafness-dystonia syndrome." Neurology. PMID:15956176
Taylor SW, et al. (2004). "Characterization of the human mitochondrial protein import machinery." J Mol Biol. PMID:15560828
Weinhäupl K, et al. (2018). "Structure of the TIM8/TIM13 complex." J Mol Biol. PMID:29588123
Timm8A Protein plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
The study of Timm8A Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.