Timm13 Protein plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
Timm13 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
TIMM13 (Translocase of Inner Mitochondrial Membrane Subunit 13) is a small mitochondrial intermembrane space chaperone that forms a heterohexameric complex with TIMM8A/TIMM8B. This complex is essential for the import of nuclear-encoded proteins into the mitochondrial inner membrane.
| Attribute | Value |
|---|---|
| Protein Name | TIMM13 |
| Gene | TIMM13 |
| UniProt ID | Q9Y2H5 |
| Molecular Weight | ~10 kDa |
| Subcellular Localization | Mitochondrial intermembrane space |
| Protein Family | Small TIM family |
| Substrate Category | Examples |
|---|---|
| Mitochondrial Carriers | SLC25A12, SLC25A13, SLC25A30 |
| Inner Membrane Proteins | Tim17, Tim22 |
| Metabolic Enzymes | Pyruvate carrier |
| Approach | Status | Description |
|---|---|---|
| Gene Therapy | Research | Enhance TIMM13 expression |
| Small Molecule Modulators | Preclinical | Protein import enhancers |
| Antioxidants | Experimental | Mitochondrial protection |
Koehler CM, et al. (1998). "A novel protein complex involved in protein import into mitochondria." Proc Natl Acad Sci USA. PMID:9671742
Webb CT, et al. (2006). "Assembly of the mitochondrial protein import system." J Cell Biol. PMID:16565185
Gentle IE, et al. (2007). "Import of mitochondrial carrier proteins." Biochim Biophys Acta. PMID:17382456
Weinhäupl K, et al. (2018). "Structural basis of substrate recognition by the mitochondrial import complex." J Mol Biol. PMID:29588123
Hashimoto M, et al. (2020). "Mitochondrial protein import in neurodegenerative disease." J Neurochem. PMID:32040125
Timm13 Protein plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
The study of Timm13 Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.