RORα Protein is involved in circadian rhythm regulation and has been implicated in neurodegenerative diseases. This page provides information about its structure, function, and role in neurodegeneration.
RORα Protein plays a critical role in the molecular circadian clock and its dysregulation may contribute to neurodegeneration.
| RORα Protein | |
|---|---|
| Protein Name | RORα Protein |
| Gene | RORA |
| UniProt ID | Q9Y5X4 |
| Molecular Weight | 59 kDa |
| Subcellular Localization | Nucleus |
| Protein Family | Nuclear receptor |
Describe the protein structure including domains and post-translational modifications.
RORα is a nuclear receptor essential for cerebellar development and circadian rhythm regulation. It regulates genes important for neuronal function and metabolism.
RORA mutations cause cerebellar ataxia in mice. Reduced RORα expression is observed in Alzheimer's disease brains.
RORα agonists may have therapeutic potential for ataxia and neurodegeneration.