RAMP3 (Receptor Activity Modifying Protein 3) partners with CALCRL to form adrenomedullin and CGRP receptors, playing roles in vascular and immune function.
RAMP3 follows the typical RAMP structure:
Adrenomedullin-RAMP3 signaling provides neuroprotection in ischemic stroke [1].
Expression altered in AD brains; may modulate neuroinflammation [2].
RAMP3 modulates inflammatory responses [3].