RAMP2 (Receptor Activity Modifying Protein 2) forms functional adrenomedullin receptors with CALCRL and is essential for vascular development and function.
RAMP2 shares the common RAMP architecture:
Adrenomedullin signaling through RAMP2-containing receptors has protective effects in cerebral ischemia [1].
AM signaling may have neuroprotective effects in AD [2].
Dysregulated RAMP2 expression in hypertension and heart failure [3].