Rab27B Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
{{Infobox protein}}
RAB27B is a member of the Rab GTPase family that plays a critical role in regulated exocytosis and intracellular vesicle trafficking. Rab27B is particularly important in controlling the transport and release of secretory granules in various cell types, including neuroendocrine cells, platelets, and melanocytes. The protein functions as a molecular switch cycling between active (GTP-bound) and inactive (GDP-bound) states, interacting with a variety of effector proteins to mediate specific trafficking events[1][2].
| Property | Value |
|---|---|
| Protein Name | RAB27B |
| Gene Symbol | RAB27B |
| UniProt ID | Q9NPF4 |
| Molecular Weight | 24.8 kDa |
| Subcellular Localization | Secretory vesicles, plasma membrane |
| Protein Family | Rab GTPase family |
| PDB Structure | 5EBM |
RAB27B contains several key structural features:
RAB27B has distinct binding surfaces for its effector proteins:
RAB27B controls several key secretion pathways:
| Process | Mechanism |
|---|---|
| Vesicle docking | Direct effector interactions |
| Peripheral transport | Actin-myosin based movement |
| Fusion competence | Munc13-4 mediated priming |
| Cargo sorting | Selective packaging into RAB27B vesicles |
| Effector | Primary Function | Interaction Domain |
|---|---|---|
| Slac2-a/MyRIP | Actin-based transport | RBD domain |
| Munc13-4 | Vesicle priming | C1/C2 domains |
| Synaptotagmin-like proteins | Calcium regulation | C2 domains |
| Granuphilin | Docking to plasma membrane | SMR domain |
[1] Fukuda, M. et al. (2002). Slac2-c (Synaptotagmin-like protein homology 4-c)/granuphilin directly regulates insulin granule exocytosis and binding to the exocyst. Journal of Biological Chemistry, 277(42), 39673-39678.
[2] Desnos, C. et al. (2003). Munc13-4 functions as a Ca2+ and Ptid-dependent secretory vesicle docking protein. Journal of Cell Biology, 162(4), 587-597.
[3]参考文献: Bendor, J. et al. (2013). The function of alpha-synuclein. Neuron, 79(6), 1044-1068.
The study of Rab27B Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
[1] Fukuda, M. et al. (2002). Slac2-c (Synaptotagmin-like protein homology 4-c)/granuphilin directly regulates insulin granule exocytosis and binding to the exocyst. Journal of Biological Chemistry, 277(42), 39673-39678. PMID:12414904
[2] Desnos, C. et al. (2003). Munc13-4 functions as a Ca2+ and Ptid-dependent secretory vesicle docking protein. Journal of Cell Biology, 162(4), 587-597. PMID:12952945
[3] Bendor, J. et al. (2013). The function of alpha-synuclein. Neuron, 79(6), 1044-1068. PMID:24065793
Note: This page is part of the NeuroWiki protein database. Last updated: 2026-03-04