Psma4 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
| Protein Name | Proteasome Subunit Alpha Type 4 |
| Gene | PSMA4 |
| UniProt ID | P25789 |
| PDB ID | 5MX3 |
| Molecular Weight | 26.5 kDa |
| Subcellular Localization | Cytoplasm, Nucleus |
| Protein Family | Proteasome alpha subunit family |
PSMA4 PROTEIN is a gene/protein encoding a key neuronal protein involved in synaptic function, signal transduction, and cellular homeostasis. Dysfunction of PSMA4 PROTEIN is associated with neurodegenerative diseases including Alzheimer's disease, Parkinson's disease, and related disorders.
PSMA4 is a 26.5 kDa α-subunit of the 20S proteasome. It is one of seven α-subunits that form the outer regulatory ring of the proteasome core particle. PSMA4 participates in substrate recognition and gate regulation.
PSMA4 contributes to proteasome function:
The study of Psma4 Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.