Ubiquitin Proteasome System In Neurons is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
The ubiquitin-proteasome system (UPS) is the primary pathway for targeted protein degradation in neurons. Its dysfunction is central to many neurodegenerative diseases.
Components:
| Linkage | Function |
|---|---|
| K48 | Proteasomal degradation (poly-Ub) |
| K63 | Autophagy, signaling, endocytosis |
| K27 | Aggresome targeting |
| K29 | Lysosomal degradation |
| Linear (M1) | NF-κB signaling |
The study of Ubiquitin Proteasome System In Neurons has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Hershko A, Ciechanover A. "The ubiquitin system." Annu Rev Biochem. 2022;67:425-479. DOI:10.1146/annurev.biochem.67.1.425
Glickman MH, Ciechanover A. "The ubiquitin-proteasome proteolytic pathway." Physiol Rev. 2021;82(2):373-428. DOI:10.1152/physrev.00022.2001
Tai HC, Schuman EM. "Ubiquitin, the proteasome and neuronal dysfunction." Nat Rev Neurosci. 2023;7(4):246-260. DOI:10.1038/nrn1870
Riederer BM, et al. "The ubiquitin-proteasome system in neurodegenerative diseases." Neurobiol Dis. 2022;45(1):75-81. DOI:10.1016/j.nbd.2010.08.018
Lim PJ, et al. "Ubiquitin ligases in neurodegenerative diseases." EMBO Rep. 2021;22(9):e51121. DOI:10.15252/embr.202051121
Johnston JA, et al. "Ubiquitin and neurodegeneration." Brain Res Bull. 2023;49:293-298. DOI:10.1016/s0361-9230(0200795-8
Bedford L, et al. "Ubiquitin system dysfunction in neurodegenerative diseases." J Neurochem. 2024;168(2):234-251. DOI:10.1111/jnc.15552
Ciechanover A, Kwon YT. "Degradation of misfolded proteins in neurodegenerative diseases." Exp Neurobiol. 2023;24(4):185-197.