Pp2A Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
| Protein Phosphatase 2A | |
|---|---|
| Protein Name | PP2A |
| Gene | PPP2CA |
| UniProt ID | P67775 |
| PDB ID | 2IAY, 3NGA |
| Molecular Weight | 36 kDa (catalytic subunit) |
| Subcellular Localization | Cytoplasm, Nucleus, Membrane |
| Protein Family | PP2A family, Ser/Thr protein phosphatase |
| Associated Diseases | Alzheimer's Disease, Parkinson's Disease, Cancer |
PP2A is a heterotrimeric enzyme composed of:
Over 15 different B subunits create diverse PP2A holoenzymes with distinct functions.
PP2A is a major neuronal phosphatase:
In Alzheimer's Disease:
In Parkinson's Disease:
PP2A is a therapeutic target:
The study of Pp2A Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
This section provides background information on the gene/protein and its role in the nervous system.
This overview section needs to be expanded with relevant scientific information from peer-reviewed sources.