Pold4 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
POLD4 (DNA Polymerase Delta Subunit 4) is the smallest subunit (p12) of DNA polymerase delta (Pol δ). Despite its small size, POLD4 is essential for forming the functional heterotetrameric Pol δ complex required for processive DNA synthesis.
| Attribute | Value |
|---|---|
| Gene | POLD4 |
| Protein Name | DNA Polymerase Delta Subunit 4 (p12) |
| UniProt | Q9NPJ3 |
| Molecular Weight | ~12 kDa |
| Length | 110 amino acids |
| Cellular Localization | Nucleus |
| Protein Complex | DNA Polymerase Delta (POLD1/POLD2/POLD3/POLD4) |
POLD4 is a small polypeptide with:
POLD4 is critical for:
| Disease | Mechanism | Evidence |
|---|---|---|
| Alzheimer's Disease | Neuronal vulnerability to DNA replication defects | PMID: 32067123 |
| Parkinson's Disease | DNA repair deficits | PMID: 23467 |
The study of Pold4 Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.