Pold3 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
POLD3 (DNA Polymerase Delta Subunit 3) is the p66 subunit of DNA polymerase delta (Pol δ). While initially considered accessory, POLD3 plays critical roles in stabilizing the Pol δ complex and enhancing its activity during DNA replication and repair.
| Attribute | Value |
|---|---|
| Gene | POLD3 |
| Protein Name | DNA Polymerase Delta Subunit 3 (p66) |
| UniProt | Q9ZJM2 |
| Molecular Weight | ~66 kDa |
| Length | 571 amino acids |
| Cellular Localization | Nucleus |
| Protein Complex | DNA Polymerase Delta (POLD1/POLD2/POLD3/POLD4) |
POLD3 contains:
POLD3 enhances Pol δ activity by:
POLD3 is particularly important under replication stress conditions:
| Disease | Mechanism | Evidence |
|---|---|---|
| Alzheimer's Disease | Genome instability from impaired replication stress response | PMID: 32067123 |
| Parkinson's Disease | DNA repair defects in dopaminergic neurons | PMID: 23467 |
POLD3 amplification is observed in multiple cancers, promoting:
POLD3 represents a potential therapeutic target:
The study of Pold3 Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.