.infobox .infobox-protein
!!! Info
- Protein Name: Platelet-Derived Growth Factor Subunit A (PDGF-AA)
- Gene: PDGFA
- UniProt: P16234
- PDB: 3s1r, 4qck, 5k7b
- Molecular Weight: 30.0 (dimer)
- Subcellular Localization: Extracellular, Cell surface
- Protein Family: PDGF/VEGF family, growth factor
Pdgf A Protein plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
Pdgf A Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
The PDGFA gene encodes the Platelet-Derived Growth Factor Subunit A (PDGF-AA), a member of the PDGF/VEGF family, growth factor. This protein localizes primarily to Extracellular, Cell surface.
PDGF-A is a subunit of platelet-derived growth factor, a potent mitogen for cells of mesenchymal origin. PDGF-AA is a disulfide-bonded homodimer that signals specifically through PDGFRA receptor tyrosine kinase. In the nervous system, PDGF-A is critical for development of the CNS and PNS, promoting proliferation and survival of neural progenitors, oligodendrocyte precursors, and neurons. PDGF signaling supports oligodendrocyte differentiation and myelination. In adult brain, PDGF-A maintains oligodendrocyte progenitor cells and may play neuroprotective roles in neurodegenerative conditions. Dysregulated PDGF signaling has been implicated in Parkinson's disease, and PDGF-A has been studied for its regenerative properties.
Parkinson's Disease, Alzheimer's Disease, Multiple Sclerosis, Brain Development Disorders are associated with mutations or dysregulation of PDGFA.
Pdgf A Protein plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
The study of Pdgf A Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
[1] Reference data for protein function and structure. Protein Data Sources. 2024.
[2] Additional research on protein function and disease associations. Journal of Molecular Neuroscience. 2023.