Lc3 (Microtubule Associated Protein 1 Light Chain 3) is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
| LC3 (Microtubule-Associated Protein 1 Light Chain 3) | |
|---|---|
| Protein Name | Microtubule-Associated Protein 1 Light Chain 3 |
| Gene | MAP1LC3A |
| UniProt | Q9H0Y1 |
| PDB ID | 2K34, 2ZTN |
| Molecular Weight | 17 kDa |
| Localization | Autophagosome |
| Protein Family | ATG8 family |
LC3 (Microtubule-Associated Protein 1 Light Chain 3) is a central protein in autophagy, forming part of the ATG8 conjugation system. LC3 is essential for autophagosome formation and serves as a marker for autophagy activity.
LC3:
LC3:
Alzheimer's Disease: LC3 altered in AD brain. Autophagy impaired.
Parkinson's Disease: LC3 in mitophagy of dopaminergic neurons.
Huntington's Disease: LC3 in mutant huntingtin clearance.
The study of Lc3 (Microtubule Associated Protein 1 Light Chain 3) has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.