P62 Protein (Sequestosome 1) is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
| Gene | SQSTM1 |
|---|---|
| UniProt ID | Q13501 |
| PDB Structures | 2K38, 5O8Y |
| Molecular Weight | ~62 kDa |
| Subcellular Localization | Cytoplasm, nucleus, aggresomes, autophagosomes |
| Protein Family | Sequestosome family |
p62 (also known as sequestosome-1 or SQSTM1) is a multifunctional adaptor protein that serves as a key regulator of selective autophagy and cellular signaling. p62 contains multiple protein-protein interaction domains allowing it to act as a scaffold for various signaling pathways and as a selective autophagy receptor for protein aggregates and damaged organelles.
p62 contains several functional domains:
p62 is a master regulator of cellular homeostasis:
| Approach | Status | Description |
|---|---|---|
| Autophagy Inducers | Research | Rapamycin, mTOR inhibitors |
| p62 Phosphorylation Modulators | Preclinical | Enhance TBK1-mediated phosphorylation |
| Nrf2 Activators | Preclinical | Bardoxolone methyl, sulforaphane |
| Gene Therapy | Research | Modulate p62 expression |
| Approach | Status | Description |
|---|---|---|
| p62 activators | Research | Boost selective autophagy |
| Nrf2 modulators | Preclinical | Target p62-Nrf2 pathway |
| Autophagy inducers | Clinical | Rapamycin, metformin |
| Gene therapy | Research | Increase p62 expression |
The study of P62 Protein (Sequestosome 1) has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
[1] Gal J et al. Neurobiol Aging. 2007;28(9):1336-1347.