Kif13A Protein plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
Kif13A Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
Protein Name: Kinesin-3 Family Member 13A
Gene: KIF13A
UniProt ID: O14763
PDB ID: 5JVG
Molecular Weight: 189 kDa
Subcellular Localization: Endosomes, Growth cones, Dendritic spines
Protein Family: Kinesin-3 family (KIF1 family)
KIF13A has a distinctive structure adapted for its function:
KIF13A is a monomeric kinesin that mediates endocytic trafficking and synaptic vesicle transport. It localizes to growth cones and dendritic spines where it regulates spine morphology and synaptic plasticity. KIF13A is involved in the transport of amyloid precursor protein (APP).
KIF13A is implicated in Charcot-Marie-Tooth disease and Parkinson's disease. It participates in APP trafficking relevant to Alzheimer's disease pathogenesis.
KIF13A represents a potential therapeutic target:
Kif13A Protein plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
The study of Kif13A Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.